EIF2A protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EIF2A

Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (585 aa)

Predicted Functional Partners:

EIF2AK2

0.834

EIF2S1

0.792

EIF2S3

0.781

EIF2AK4

0.736

EIF3B

0.689

G3BP1

0.689

XRN1

0.674

EIF2S2

0.659

EIF2AK1

0.641

EIF2AK3

0.630

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF2A	EIF2AK1	ENSCAFP00000012365	ENSCAFP00000023026	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 alpha kinase 1.	0.641
EIF2A	EIF2AK2	ENSCAFP00000012365	ENSCAFP00000009092	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.834
EIF2A	EIF2AK3	ENSCAFP00000012365	ENSCAFP00000010977	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.630
EIF2A	EIF2AK4	ENSCAFP00000012365	ENSCAFP00000012980	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.736
EIF2A	EIF2S1	ENSCAFP00000012365	ENSCAFP00000034264	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 subunit alpha.	0.792
EIF2A	EIF2S2	ENSCAFP00000012365	ENSCAFP00000011141	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 subunit beta.	0.659
EIF2A	EIF2S3	ENSCAFP00000012365	ENSCAFP00000047490	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 2 subunit gamma.	0.781
EIF2A	EIF3B	ENSCAFP00000012365	ENSCAFP00000024173	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.	0.689
EIF2A	G3BP1	ENSCAFP00000012365	ENSCAFP00000054602	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	G3BP stress granule assembly factor 1.	0.689
EIF2A	XRN1	ENSCAFP00000012365	ENSCAFP00000051235	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	5'-3' exoribonuclease 1.	0.674
EIF2AK1	EIF2A	ENSCAFP00000023026	ENSCAFP00000012365	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	0.641
EIF2AK1	EIF2AK2	ENSCAFP00000023026	ENSCAFP00000009092	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2-alpha kinase 2.	0.862
EIF2AK1	EIF2AK3	ENSCAFP00000023026	ENSCAFP00000010977	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.848
EIF2AK1	EIF2AK4	ENSCAFP00000023026	ENSCAFP00000012980	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.853
EIF2AK1	EIF2S1	ENSCAFP00000023026	ENSCAFP00000034264	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 subunit alpha.	0.993
EIF2AK1	EIF2S2	ENSCAFP00000023026	ENSCAFP00000011141	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 subunit beta.	0.678
EIF2AK1	EIF2S3	ENSCAFP00000023026	ENSCAFP00000047490	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 subunit gamma.	0.814
EIF2AK2	EIF2A	ENSCAFP00000009092	ENSCAFP00000012365	Eukaryotic translation initiation factor 2-alpha kinase 2.	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.	0.834
EIF2AK2	EIF2AK1	ENSCAFP00000009092	ENSCAFP00000023026	Eukaryotic translation initiation factor 2-alpha kinase 2.	Eukaryotic translation initiation factor 2 alpha kinase 1.	0.862
EIF2AK2	EIF2AK3	ENSCAFP00000009092	ENSCAFP00000010977	Eukaryotic translation initiation factor 2-alpha kinase 2.	Eukaryotic translation initiation factor 2 alpha kinase 3.	0.824

page 1 of 4

Server load: low (22%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About