PAG1 protein (Canis lupus familiaris) - STRING interaction network

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Score

PAG1

Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (433 aa)

Predicted Functional Partners:

CSK

0.982

LYN

0.900

MATK

0.826

LCK

0.768

SRC

0.718

FYN

0.667

SRMS

0.667

GRB2

0.617

CD3E

0.589

PTPN11

0.570

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3E	CSK	ENSCAFP00000052947	ENSCAFP00000026494	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.690
CD3E	FYN	ENSCAFP00000052947	ENSCAFP00000005934	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.836
CD3E	LCK	ENSCAFP00000052947	ENSCAFP00000015667	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.918
CD3E	LYN	ENSCAFP00000052947	ENSCAFP00000046785	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.521
CD3E	PAG1	ENSCAFP00000052947	ENSCAFP00000012389	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.589
CD3E	PTPN11	ENSCAFP00000052947	ENSCAFP00000013074	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.581
CD3E	SRC	ENSCAFP00000052947	ENSCAFP00000044994	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.521
CD3E	SRMS	ENSCAFP00000052947	ENSCAFP00000019074	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.836
CSK	CD3E	ENSCAFP00000026494	ENSCAFP00000052947	Tyrosine-protein kinase.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.690
CSK	FYN	ENSCAFP00000026494	ENSCAFP00000005934	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.521
CSK	GRB2	ENSCAFP00000026494	ENSCAFP00000049390	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.779
CSK	LCK	ENSCAFP00000026494	ENSCAFP00000015667	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.729
CSK	LYN	ENSCAFP00000026494	ENSCAFP00000046785	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.696
CSK	PAG1	ENSCAFP00000026494	ENSCAFP00000012389	Tyrosine-protein kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.982
CSK	PTPN11	ENSCAFP00000026494	ENSCAFP00000013074	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.699
CSK	SRC	ENSCAFP00000026494	ENSCAFP00000044994	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.966
CSK	SRMS	ENSCAFP00000026494	ENSCAFP00000019074	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.456
FYN	CD3E	ENSCAFP00000005934	ENSCAFP00000052947	Tyrosine-protein kinase.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.836
FYN	CSK	ENSCAFP00000005934	ENSCAFP00000026494	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.521
FYN	GRB2	ENSCAFP00000005934	ENSCAFP00000049390	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.772