STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLX2T cell leukemia homeobox 2. (284 aa)    
Predicted Functional Partners:
LDB1
LIM domain binding 1.
   
  
 0.669
ARX
Aristaless related homeobox.
   
 
0.596
ZNRF1
Zinc and ring finger 1.
      
 0.493
NR2F1
Nuclear receptor subfamily 2 group F member 1.
      
 0.489
NFE2
Nuclear factor, erythroid 2.
      
 0.485
UNCX
UNC homeobox.
   
 
 0.432
NFIC
Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
   
 
 0.432
PAX4
Paired box 4.
   
 
 0.415
SNIP1
Smad nuclear interacting protein 1.
      
 0.407
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.