EPHX2 protein (Canis lupus familiaris) - STRING interaction network

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Score

EPHX2

Epoxide hydrolase 2. (556 aa)

Predicted Functional Partners:

CYP2J2

0.966

EPHX1

0.962

EPHX3

0.923

CYP1A1

0.895

CYP1B1

0.894

AKR1A1

0.894

PNP

0.852

NUDT12

0.851

MTAP

0.846

AKR1C3

0.826

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1A1	AKR1C3	ENSCAFP00000057072	ENSCAFP00000007901	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.882
AKR1A1	CYP1B1	ENSCAFP00000057072	ENSCAFP00000009250	Aldo_ket_red domain-containing protein.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.442
AKR1A1	EPHX1	ENSCAFP00000057072	ENSCAFP00000050973	Aldo_ket_red domain-containing protein.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.894
AKR1A1	EPHX2	ENSCAFP00000057072	ENSCAFP00000012415	Aldo_ket_red domain-containing protein.	Epoxide hydrolase 2.	0.894
AKR1A1	EPHX3	ENSCAFP00000057072	ENSCAFP00000040131	Aldo_ket_red domain-containing protein.	Epoxide hydrolase 3.	0.885
AKR1C3	AKR1A1	ENSCAFP00000007901	ENSCAFP00000057072	Aldo_ket_red domain-containing protein.	Aldo_ket_red domain-containing protein.	0.882
AKR1C3	CYP1A1	ENSCAFP00000007901	ENSCAFP00000065547	Aldo_ket_red domain-containing protein.	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	0.893
AKR1C3	CYP1B1	ENSCAFP00000007901	ENSCAFP00000009250	Aldo_ket_red domain-containing protein.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.891
AKR1C3	EPHX1	ENSCAFP00000007901	ENSCAFP00000050973	Aldo_ket_red domain-containing protein.	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.820
AKR1C3	EPHX2	ENSCAFP00000007901	ENSCAFP00000012415	Aldo_ket_red domain-containing protein.	Epoxide hydrolase 2.	0.826
AKR1C3	EPHX3	ENSCAFP00000007901	ENSCAFP00000040131	Aldo_ket_red domain-containing protein.	Epoxide hydrolase 3.	0.885
CYP1A1	AKR1C3	ENSCAFP00000065547	ENSCAFP00000007901	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Aldo_ket_red domain-containing protein.	0.893
CYP1A1	CYP1B1	ENSCAFP00000065547	ENSCAFP00000009250	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.909
CYP1A1	CYP2J2	ENSCAFP00000065547	ENSCAFP00000027833	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family.	0.909
CYP1A1	EPHX1	ENSCAFP00000065547	ENSCAFP00000050973	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.	0.952
CYP1A1	EPHX2	ENSCAFP00000065547	ENSCAFP00000012415	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Epoxide hydrolase 2.	0.895
CYP1A1	EPHX3	ENSCAFP00000065547	ENSCAFP00000040131	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	Epoxide hydrolase 3.	0.901
CYP1B1	AKR1A1	ENSCAFP00000009250	ENSCAFP00000057072	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.442
CYP1B1	AKR1C3	ENSCAFP00000009250	ENSCAFP00000007901	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.891
CYP1B1	CYP1A1	ENSCAFP00000009250	ENSCAFP00000065547	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...]	0.909