STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CALCBCalcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. (264 aa)    
Predicted Functional Partners:
CALCRL
Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.958
RAMP1
Receptor activity modifying protein 1.
    
 0.953
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.924
RAMP2
Uncharacterized protein.
    
 0.851
IAPP
Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family.
     
 0.799
CRSP-4
Calcitonin receptor-stimulating peptide 2.
   
 
 0.798
ADM
Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents; Belongs to the adrenomedullin family.
     
 0.796
RAMP3
Receptor activity modifying protein 3.
     
 0.795
ADM2
Adrenomedullin 2.
     
 0.730
CALCA
Calcitonin gene-related peptide 1; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).
   
 
 0.722
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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