STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF319Zinc finger protein 319. (612 aa)    
Predicted Functional Partners:
JOSD1
Josephin domain containing 1.
      
 0.563
UBA2
SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.
    
 
 0.563
HUWE1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
   
 
 0.552
UBE2O
Ubiquitin conjugating enzyme E2 O.
    
 
 0.550
UBE2Z
Ubiquitin conjugating enzyme E2 Z.
    
 
 0.547
KIAA0040
KIAA0040.
      
 0.543
RNF25
Ring finger protein 25.
   
  
 0.526
HERC4
HECT and RLD domain containing E3 ubiquitin protein ligase 4.
      
 0.518
ENSCAFP00000064886
Uncharacterized protein.
      
 0.515
ENSCAFP00000066593
C2H2-type domain-containing protein.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.