SUCNR1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SUCNR1

Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)

Predicted Functional Partners:

SST

0.803

GHRL

0.802

OXT

0.789

EDN1

0.786

EDN3

0.784

EDN2

0.781

APPBP2

0.689

AADACL2

0.677

AADAC

0.672

DHDH

0.629

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AADAC	APPBP2	ENSCAFP00000012573	ENSCAFP00000026204	Arylacetamide deacetylase.	Amyloid beta precursor protein binding protein 2.	0.813
AADAC	DHDH	ENSCAFP00000012573	ENSCAFP00000005770	Arylacetamide deacetylase.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.649
AADAC	SUCNR1	ENSCAFP00000012573	ENSCAFP00000012574	Arylacetamide deacetylase.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.672
AADACL2	SUCNR1	ENSCAFP00000012537	ENSCAFP00000012574	Arylacetamide deacetylase like 2.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.677
APPBP2	AADAC	ENSCAFP00000026204	ENSCAFP00000012573	Amyloid beta precursor protein binding protein 2.	Arylacetamide deacetylase.	0.813
APPBP2	DHDH	ENSCAFP00000026204	ENSCAFP00000005770	Amyloid beta precursor protein binding protein 2.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.868
APPBP2	SUCNR1	ENSCAFP00000026204	ENSCAFP00000012574	Amyloid beta precursor protein binding protein 2.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.689
DHDH	AADAC	ENSCAFP00000005770	ENSCAFP00000012573	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Arylacetamide deacetylase.	0.649
DHDH	APPBP2	ENSCAFP00000005770	ENSCAFP00000026204	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Amyloid beta precursor protein binding protein 2.	0.868
DHDH	SUCNR1	ENSCAFP00000005770	ENSCAFP00000012574	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.629
EDN1	EDN2	ENSCAFP00000014389	ENSCAFP00000003751	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	0.943
EDN1	EDN3	ENSCAFP00000014389	ENSCAFP00000018044	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.908
EDN1	GHRL	ENSCAFP00000014389	ENSCAFP00000007641	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.532
EDN1	OXT	ENSCAFP00000014389	ENSCAFP00000048730	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family.	0.525
EDN1	SUCNR1	ENSCAFP00000014389	ENSCAFP00000012574	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.786
EDN2	EDN1	ENSCAFP00000003751	ENSCAFP00000014389	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.943
EDN2	EDN3	ENSCAFP00000003751	ENSCAFP00000018044	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.	0.909
EDN2	GHRL	ENSCAFP00000003751	ENSCAFP00000007641	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.423
EDN2	OXT	ENSCAFP00000003751	ENSCAFP00000048730	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family.	0.400
EDN2	SUCNR1	ENSCAFP00000003751	ENSCAFP00000012574	Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family.	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.781