STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (950 aa)    
Predicted Functional Partners:
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif 4.
  
 
0.741
ACAN
Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
    
 
 0.667
THBS1
Thrombospondin 1.
    
0.625
SSPO
SCO-spondin.
   
0.605
ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif 2.
  
 
0.593
USF2
Upstream transcription factor 2, c-fos interacting.
    
 
 0.585
RARRES2
Retinoic acid receptor responder 2.
      
 0.567
MMP13
Matrix metallopeptidase 13.
    
 
 0.566
MMP24
Matrix metallopeptidase 24.
    
 
 0.565
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif 5.
  
 
0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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