ADAMTS5 protein (Canis lupus familiaris) - STRING interaction network

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ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif 5. (845 aa)

Predicted Functional Partners:

ACAN

0.906

MMP13

0.902

MMP3

0.875

BCAN

0.872

COL2A1

0.839

IL1B

0.725

TIMP3

0.710

MMP9

0.643

COL10A1

0.638

AACS

0.611

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ADAMTS5	ENSCAFP00000055802	ENSCAFP00000012608	Transmembrane protein 132B.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.611
ACAN	ADAMTS5	ENSCAFP00000065577	ENSCAFP00000012608	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.906
ACAN	BCAN	ENSCAFP00000065577	ENSCAFP00000024595	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Uncharacterized protein.	0.587
ACAN	COL10A1	ENSCAFP00000065577	ENSCAFP00000039411	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen type X alpha 1 chain.	0.828
ACAN	COL2A1	ENSCAFP00000065577	ENSCAFP00000013330	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Collagen type II alpha 1 chain.	0.953
ACAN	IL1B	ENSCAFP00000065577	ENSCAFP00000010762	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.754
ACAN	MMP13	ENSCAFP00000065577	ENSCAFP00000022174	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrix metallopeptidase 13.	0.928
ACAN	MMP3	ENSCAFP00000065577	ENSCAFP00000022195	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.895
ACAN	MMP9	ENSCAFP00000065577	ENSCAFP00000035167	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.698
ACAN	TIMP3	ENSCAFP00000065577	ENSCAFP00000040576	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	TIMP metallopeptidase inhibitor 3.	0.602
ADAMTS5	AACS	ENSCAFP00000012608	ENSCAFP00000055802	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Transmembrane protein 132B.	0.611
ADAMTS5	ACAN	ENSCAFP00000012608	ENSCAFP00000065577	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	0.906
ADAMTS5	BCAN	ENSCAFP00000012608	ENSCAFP00000024595	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Uncharacterized protein.	0.872
ADAMTS5	COL10A1	ENSCAFP00000012608	ENSCAFP00000039411	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Collagen type X alpha 1 chain.	0.638
ADAMTS5	COL2A1	ENSCAFP00000012608	ENSCAFP00000013330	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Collagen type II alpha 1 chain.	0.839
ADAMTS5	IL1B	ENSCAFP00000012608	ENSCAFP00000010762	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.725
ADAMTS5	MMP13	ENSCAFP00000012608	ENSCAFP00000022174	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metallopeptidase 13.	0.902
ADAMTS5	MMP3	ENSCAFP00000012608	ENSCAFP00000022195	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.	0.875
ADAMTS5	MMP9	ENSCAFP00000012608	ENSCAFP00000035167	ADAM metallopeptidase with thrombospondin type 1 motif 5.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.643
ADAMTS5	TIMP3	ENSCAFP00000012608	ENSCAFP00000040576	ADAM metallopeptidase with thrombospondin type 1 motif 5.	TIMP metallopeptidase inhibitor 3.	0.710