TDO2 protein (Canis lupus familiaris) - STRING interaction network

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TDO2

Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)

Predicted Functional Partners:

KYNU

0.996

IDO1

0.989

IDO2

0.988

BIRC5

0.953

TPH1

0.945

DDC

0.941

TPH2

0.932

KMO

0.922

IL4I1

0.901

E2R735_CANLF

0.899

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC5	DDC	ENSCAFP00000045531	ENSCAFP00000005077	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Dopa decarboxylase.	0.892
BIRC5	IDO1	ENSCAFP00000045531	ENSCAFP00000062598	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Indoleamine 2,3-dioxygenase 1.	0.927
BIRC5	IDO2	ENSCAFP00000045531	ENSCAFP00000043401	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Indoleamine 2,3-dioxygenase 2.	0.949
BIRC5	KMO	ENSCAFP00000045531	ENSCAFP00000023107	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.951
BIRC5	KYNU	ENSCAFP00000045531	ENSCAFP00000008166	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.953
BIRC5	TDO2	ENSCAFP00000045531	ENSCAFP00000012609	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.953
DDC	BIRC5	ENSCAFP00000005077	ENSCAFP00000045531	Dopa decarboxylase.	Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]	0.892
DDC	E2R735_CANLF	ENSCAFP00000005077	ENSCAFP00000003629	Dopa decarboxylase.	Amino_oxidase domain-containing protein.	0.887
DDC	IDO1	ENSCAFP00000005077	ENSCAFP00000062598	Dopa decarboxylase.	Indoleamine 2,3-dioxygenase 1.	0.947
DDC	IDO2	ENSCAFP00000005077	ENSCAFP00000043401	Dopa decarboxylase.	Indoleamine 2,3-dioxygenase 2.	0.936
DDC	IL4I1	ENSCAFP00000005077	ENSCAFP00000005131	Dopa decarboxylase.	Interleukin 4 induced 1.	0.887
DDC	KMO	ENSCAFP00000005077	ENSCAFP00000023107	Dopa decarboxylase.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.521
DDC	KYNU	ENSCAFP00000005077	ENSCAFP00000008166	Dopa decarboxylase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.436
DDC	TDO2	ENSCAFP00000005077	ENSCAFP00000012609	Dopa decarboxylase.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.941
DDC	TPH1	ENSCAFP00000005077	ENSCAFP00000043863	Dopa decarboxylase.	Tryptophan hydroxylase 1.	0.944
DDC	TPH2	ENSCAFP00000005077	ENSCAFP00000000683	Dopa decarboxylase.	Tryptophan hydroxylase 2.	0.938
E2R735_CANLF	DDC	ENSCAFP00000003629	ENSCAFP00000005077	Amino_oxidase domain-containing protein.	Dopa decarboxylase.	0.887
E2R735_CANLF	IDO1	ENSCAFP00000003629	ENSCAFP00000062598	Amino_oxidase domain-containing protein.	Indoleamine 2,3-dioxygenase 1.	0.898
E2R735_CANLF	IDO2	ENSCAFP00000003629	ENSCAFP00000043401	Amino_oxidase domain-containing protein.	Indoleamine 2,3-dioxygenase 2.	0.893
E2R735_CANLF	IL4I1	ENSCAFP00000003629	ENSCAFP00000005131	Amino_oxidase domain-containing protein.	Interleukin 4 induced 1.	0.881

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