STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSOCathepsin O; Belongs to the peptidase C1 family. (315 aa)    
Predicted Functional Partners:
BCL2L1
BCL2 like 1.
   
 
 0.902
BID
BH3 interacting domain death agonist.
   
 
  0.901
RBM46
RNA binding motif protein 46.
   
  
 0.854
GUCY1B1
Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.
      
 0.819
GUCY1A1
Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
      
 0.735
NPY2R
Neuropeptide Y receptor Y2.
      
 0.678
KCNJ10
Potassium voltage-gated channel subfamily J member 10.
      
 0.667
BIRC5
Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...]
   
 0.663
BIRC2
Baculoviral IAP repeat containing 2.
     
 0.660
XIAP
Baculoviral IAP-repeat containing protein 4.
   
 
 0.660
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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