STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NDRG3NDRG family member 3. (375 aa)    
Predicted Functional Partners:
HDHD3
Haloacid dehalogenase like hydrolase domain containing 3.
   
 
 0.816
PPP4R2
Protein phosphatase 4 regulatory subunit 2.
      
 0.785
ZDHHC21
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
   
  
 0.774
CREG1
Cellular repressor of E1A stimulated genes 1; Belongs to the CREG family.
      
 0.717
SNX19
Sorting nexin 19.
      
 0.657
CHMP1A
Charged multivesicular body protein 1A.
   
  
 0.653
GRID2
Glutamate ionotropic receptor delta type subunit 2.
   
  
 0.653
TXLNG
Taxilin gamma.
   
  
 0.647
VPS13C
Vacuolar protein sorting 13 homolog C.
   
  
 0.580
RAB22A
Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (By similarity). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form.
   
  
 0.578
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.