Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
USP16Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (826 aa)    
Predicted Functional Partners:
RWDD2B
RWD domain-containing protein.
   
  
 0.885
USP45
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
     
  0.881
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2.
    
 
 0.841
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 
 0.811
UBB
Ubiquitin B.
    
 
 0.693
LOC100685053
Ubiquitin-like domain-containing protein.
    
 
 0.693
KIF13A
Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.690
ZRANB1
Zinc finger RANBP2-type containing 1.
   
 
 0.661
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.
    
 
 0.618
PHTF1
Putative homeodomain transcription factor 1.
   
  
 0.603
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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