ARHGEF26 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

ARHGEF26

Rho guanine nucleotide exchange factor 26. (594 aa)

Predicted Functional Partners:

RHOG

0.905

LOC491949

0.849

MAGI2

0.769

CDC42-2

0.637

RAC1

0.576

RHOC

0.560

RHOBTB3

0.532

EVI5

0.530

PEX5L

0.522

LRRC46

0.502

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF26	CDC42-2	ENSCAFP00000012677	ENSCAFP00000060180	Rho guanine nucleotide exchange factor 26.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.637
ARHGEF26	EVI5	ENSCAFP00000012677	ENSCAFP00000065540	Rho guanine nucleotide exchange factor 26.	Rab-GAP TBC domain-containing protein.	0.530
ARHGEF26	LOC491949	ENSCAFP00000012677	ENSCAFP00000025159	Rho guanine nucleotide exchange factor 26.	Uncharacterized protein.	0.849
ARHGEF26	LRRC46	ENSCAFP00000012677	ENSCAFP00000042601	Rho guanine nucleotide exchange factor 26.	Leucine rich repeat containing 46.	0.502
ARHGEF26	MAGI2	ENSCAFP00000012677	ENSCAFP00000006489	Rho guanine nucleotide exchange factor 26.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.769
ARHGEF26	PEX5L	ENSCAFP00000012677	ENSCAFP00000049486	Rho guanine nucleotide exchange factor 26.	Peroxisomal biogenesis factor 5 like.	0.522
ARHGEF26	RAC1	ENSCAFP00000012677	ENSCAFP00000032062	Rho guanine nucleotide exchange factor 26.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.576
ARHGEF26	RHOBTB3	ENSCAFP00000012677	ENSCAFP00000011685	Rho guanine nucleotide exchange factor 26.	Rho related BTB domain containing 3.	0.532
ARHGEF26	RHOC	ENSCAFP00000012677	ENSCAFP00000059310	Rho guanine nucleotide exchange factor 26.	Uncharacterized protein.	0.560
ARHGEF26	RHOG	ENSCAFP00000012677	ENSCAFP00000008817	Rho guanine nucleotide exchange factor 26.	Ras homolog family member G.	0.905
CDC42-2	ARHGEF26	ENSCAFP00000060180	ENSCAFP00000012677	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho guanine nucleotide exchange factor 26.	0.637
CDC42-2	MAGI2	ENSCAFP00000060180	ENSCAFP00000006489	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.485
CDC42-2	RAC1	ENSCAFP00000060180	ENSCAFP00000032062	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.944
CDC42-2	RHOC	ENSCAFP00000060180	ENSCAFP00000059310	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Uncharacterized protein.	0.524
CDC42-2	RHOG	ENSCAFP00000060180	ENSCAFP00000008817	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Ras homolog family member G.	0.490
EVI5	ARHGEF26	ENSCAFP00000065540	ENSCAFP00000012677	Rab-GAP TBC domain-containing protein.	Rho guanine nucleotide exchange factor 26.	0.530
EVI5	RHOBTB3	ENSCAFP00000065540	ENSCAFP00000011685	Rab-GAP TBC domain-containing protein.	Rho related BTB domain containing 3.	0.510
LOC491949	ARHGEF26	ENSCAFP00000025159	ENSCAFP00000012677	Uncharacterized protein.	Rho guanine nucleotide exchange factor 26.	0.849
LOC491949	RAC1	ENSCAFP00000025159	ENSCAFP00000032062	Uncharacterized protein.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.417
LOC491949	RHOG	ENSCAFP00000025159	ENSCAFP00000008817	Uncharacterized protein.	Ras homolog family member G.	0.719