TLL2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TLL2

Metalloendopeptidase. (1021 aa)

Predicted Functional Partners:

PCOLCE

0.950

CHRD

0.748

OMA1

0.647

MSTN

0.640

MME

0.605

GMNC

0.591

IDE

0.557

TOB1

0.519

LOXL3

0.518

ZNF398

0.516

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHRD	MSTN	ENSCAFP00000041950	ENSCAFP00000013840	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	0.465
CHRD	TLL2	ENSCAFP00000041950	ENSCAFP00000012707	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	Metalloendopeptidase.	0.748
GMNC	TLL2	ENSCAFP00000039030	ENSCAFP00000012707	Geminin coiled-coil domain containing.	Metalloendopeptidase.	0.591
GMNC	ZNF398	ENSCAFP00000039030	ENSCAFP00000006613	Geminin coiled-coil domain containing.	Zinc finger protein 398.	0.763
IDE	MME	ENSCAFP00000011097	ENSCAFP00000064509	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Uncharacterized protein.	0.913
IDE	TLL2	ENSCAFP00000011097	ENSCAFP00000012707	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Metalloendopeptidase.	0.557
LOXL3	PCOLCE	ENSCAFP00000052850	ENSCAFP00000049022	Lysyl oxidase like 3.	Procollagen C-endopeptidase enhancer.	0.469
LOXL3	TLL2	ENSCAFP00000052850	ENSCAFP00000012707	Lysyl oxidase like 3.	Metalloendopeptidase.	0.518
MME	IDE	ENSCAFP00000064509	ENSCAFP00000011097	Uncharacterized protein.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.913
MME	TLL2	ENSCAFP00000064509	ENSCAFP00000012707	Uncharacterized protein.	Metalloendopeptidase.	0.605
MSTN	CHRD	ENSCAFP00000013840	ENSCAFP00000041950	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.465
MSTN	TLL2	ENSCAFP00000013840	ENSCAFP00000012707	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	Metalloendopeptidase.	0.640
OMA1	TLL2	ENSCAFP00000027897	ENSCAFP00000012707	OMA1 zinc metallopeptidase.	Metalloendopeptidase.	0.647
PCOLCE	LOXL3	ENSCAFP00000049022	ENSCAFP00000052850	Procollagen C-endopeptidase enhancer.	Lysyl oxidase like 3.	0.469
PCOLCE	TLL2	ENSCAFP00000049022	ENSCAFP00000012707	Procollagen C-endopeptidase enhancer.	Metalloendopeptidase.	0.950
TLL2	CHRD	ENSCAFP00000012707	ENSCAFP00000041950	Metalloendopeptidase.	Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.	0.748
TLL2	GMNC	ENSCAFP00000012707	ENSCAFP00000039030	Metalloendopeptidase.	Geminin coiled-coil domain containing.	0.591
TLL2	IDE	ENSCAFP00000012707	ENSCAFP00000011097	Metalloendopeptidase.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.557
TLL2	LOXL3	ENSCAFP00000012707	ENSCAFP00000052850	Metalloendopeptidase.	Lysyl oxidase like 3.	0.518
TLL2	MME	ENSCAFP00000012707	ENSCAFP00000064509	Metalloendopeptidase.	Uncharacterized protein.	0.605