PRKCD protein (Canis lupus familiaris) - STRING interaction network

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PRKCD

Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...] (674 aa)

Predicted Functional Partners:

PRKCA

0.961

PRKCB

0.961

SRC

0.944

CARD11

0.928

IRS2

0.925

IRS4

0.924

MARCKS

0.924

PLCG2

0.917

PRKCE

0.917

PLCG1

0.916

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	PLCG2	ENSCAFP00000023996	ENSCAFP00000029622	Caspase recruitment domain family member 11.	Phosphoinositide phospholipase C.	0.411
CARD11	PRKCA	ENSCAFP00000023996	ENSCAFP00000016686	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.833
CARD11	PRKCB	ENSCAFP00000023996	ENSCAFP00000025992	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.978
CARD11	PRKCD	ENSCAFP00000023996	ENSCAFP00000012799	Caspase recruitment domain family member 11.	Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]	0.928
CARD11	PRKCE	ENSCAFP00000023996	ENSCAFP00000047064	Caspase recruitment domain family member 11.	Protein kinase C.	0.719
IRS2	IRS4	ENSCAFP00000009098	ENSCAFP00000026634	Insulin receptor substrate 2.	Insulin receptor substrate 4.	0.850
IRS2	PRKCA	ENSCAFP00000009098	ENSCAFP00000016686	Insulin receptor substrate 2.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.916
IRS2	PRKCB	ENSCAFP00000009098	ENSCAFP00000025992	Insulin receptor substrate 2.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.916
IRS2	PRKCD	ENSCAFP00000009098	ENSCAFP00000012799	Insulin receptor substrate 2.	Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]	0.925
IRS2	PRKCE	ENSCAFP00000009098	ENSCAFP00000047064	Insulin receptor substrate 2.	Protein kinase C.	0.900
IRS2	SRC	ENSCAFP00000009098	ENSCAFP00000044994	Insulin receptor substrate 2.	Tyrosine-protein kinase.	0.408
IRS4	IRS2	ENSCAFP00000026634	ENSCAFP00000009098	Insulin receptor substrate 4.	Insulin receptor substrate 2.	0.850
IRS4	PRKCA	ENSCAFP00000026634	ENSCAFP00000016686	Insulin receptor substrate 4.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.712
IRS4	PRKCB	ENSCAFP00000026634	ENSCAFP00000025992	Insulin receptor substrate 4.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.712
IRS4	PRKCD	ENSCAFP00000026634	ENSCAFP00000012799	Insulin receptor substrate 4.	Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]	0.924
IRS4	PRKCE	ENSCAFP00000026634	ENSCAFP00000047064	Insulin receptor substrate 4.	Protein kinase C.	0.900
MARCKS	PRKCA	ENSCAFP00000064794	ENSCAFP00000016686	Myristoylated alanine rich protein kinase C substrate.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.518
MARCKS	PRKCB	ENSCAFP00000064794	ENSCAFP00000025992	Myristoylated alanine rich protein kinase C substrate.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.440
MARCKS	PRKCD	ENSCAFP00000064794	ENSCAFP00000012799	Myristoylated alanine rich protein kinase C substrate.	Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]	0.924
MARCKS	PRKCE	ENSCAFP00000064794	ENSCAFP00000047064	Myristoylated alanine rich protein kinase C substrate.	Protein kinase C.	0.891

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