STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)    
Predicted Functional Partners:
PSMC5
Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family.
  
0.999
PSMC2
Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family.
  
0.998
PSMC4
Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.
  
0.998
PSMD2
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
   
 0.998
PSMD4
Proteasome 26S subunit, non-ATPase 4.
   
 0.996
PSMC1
Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family.
  
0.996
PSMD1
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
   
 0.995
PSMD11
Proteasome 26S subunit, non-ATPase 11.
   
 0.993
PSMD13
Proteasome 26S subunit, non-ATPase 13.
   
 0.993
PSMC6
AAA domain-containing protein; Belongs to the AAA ATPase family.
  
0.993
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.