SPI1 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

SPI1

Spi-1 proto-oncogene. (358 aa)

Predicted Functional Partners:

CSF1R

0.966

RUNX1

0.937

FLT3

0.919

FCGR1A

0.915

RARA

0.911

PML

0.906

SRF

0.818

SERPINA1

0.791

IRF8

0.781

CEBPE

0.698

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEBPE	IRF8	ENSCAFP00000016806	ENSCAFP00000052304	CCAAT enhancer binding protein epsilon.	Interferon regulatory factor 8.	0.640
CEBPE	RUNX1	ENSCAFP00000016806	ENSCAFP00000014111	CCAAT enhancer binding protein epsilon.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.423
CEBPE	SPI1	ENSCAFP00000016806	ENSCAFP00000012822	CCAAT enhancer binding protein epsilon.	Spi-1 proto-oncogene.	0.698
CSF1R	FCGR1A	ENSCAFP00000053521	ENSCAFP00000016903	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.483
CSF1R	IRF8	ENSCAFP00000053521	ENSCAFP00000052304	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Interferon regulatory factor 8.	0.634
CSF1R	RUNX1	ENSCAFP00000053521	ENSCAFP00000014111	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.920
CSF1R	SPI1	ENSCAFP00000053521	ENSCAFP00000012822	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Spi-1 proto-oncogene.	0.966
FCGR1A	CSF1R	ENSCAFP00000016903	ENSCAFP00000053521	Uncharacterized protein.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.483
FCGR1A	SPI1	ENSCAFP00000016903	ENSCAFP00000012822	Uncharacterized protein.	Spi-1 proto-oncogene.	0.915
FLT3	IRF8	ENSCAFP00000051387	ENSCAFP00000052304	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Interferon regulatory factor 8.	0.429
FLT3	RARA	ENSCAFP00000051387	ENSCAFP00000010481	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...]	0.411
FLT3	RUNX1	ENSCAFP00000051387	ENSCAFP00000014111	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.425
FLT3	SPI1	ENSCAFP00000051387	ENSCAFP00000012822	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Spi-1 proto-oncogene.	0.919
IRF8	CEBPE	ENSCAFP00000052304	ENSCAFP00000016806	Interferon regulatory factor 8.	CCAAT enhancer binding protein epsilon.	0.640
IRF8	CSF1R	ENSCAFP00000052304	ENSCAFP00000053521	Interferon regulatory factor 8.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.634
IRF8	FLT3	ENSCAFP00000052304	ENSCAFP00000051387	Interferon regulatory factor 8.	Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.429
IRF8	RUNX1	ENSCAFP00000052304	ENSCAFP00000014111	Interferon regulatory factor 8.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.439
IRF8	SPI1	ENSCAFP00000052304	ENSCAFP00000012822	Interferon regulatory factor 8.	Spi-1 proto-oncogene.	0.781
PML	RARA	ENSCAFP00000049416	ENSCAFP00000010481	Promyelocytic leukemia.	Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...]	0.961
PML	RUNX1	ENSCAFP00000049416	ENSCAFP00000014111	Promyelocytic leukemia.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.916