STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
THBS1Thrombospondin 1. (1456 aa)    
Predicted Functional Partners:
ITGB3
Integrin beta; Belongs to the integrin beta chain family.
   
 0.984
CD36
CD36 molecule; Belongs to the CD36 family.
    
 0.969
CD47
CD47 molecule.
   
 0.965
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.963
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
   
 0.956
ITGA3
Integrin subunit alpha 3; Belongs to the integrin alpha chain family.
   
 0.950
MMP9
Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).
    
 0.948
ITGA4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
   
 0.944
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
    
 0.942
LTBP1
Latent transforming growth factor beta binding protein 1.
   
 
 0.937
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.