STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (315 aa)    
Predicted Functional Partners:
GLRX3
Glutaredoxin 3.
   
 
 0.981
BOLA1
BolA family member 1; Belongs to the BolA/IbaG family.
    
 
 0.962
NDOR1
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
   
 
 0.960
BOLA2B
Uncharacterized protein; Belongs to the BolA/IbaG family.
    
 
 0.896
CIAO2B
Cytosolic iron-sulfur assembly component 2B.
      
 0.789
CACNB3
Calcium voltage-gated channel auxiliary subunit beta 3.
    
 
 0.786
RGS20
Regulator of G protein signaling 20.
    
   0.768
CIAO2A
Cytosolic iron-sulfur assembly component 2A.
      
 0.761
ENSCAFP00000063468
Uncharacterized protein; Belongs to the BolA/IbaG family.
    
 
 0.757
SDR42E1
Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family.
   
 
 0.748
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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