| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCR2 | CCR5 | ENSCAFP00000020334 | ENSCAFP00000020323 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.843 |
| CCR2 | CCR7 | ENSCAFP00000020334 | ENSCAFP00000041961 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.699 |
| CCR2 | CX3CL1 | ENSCAFP00000020334 | ENSCAFP00000012877 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | Chemokine (C-X3-C motif) ligand 1. | 0.926 |
| CCR2 | CX3CR1 | ENSCAFP00000020334 | ENSCAFP00000042683 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.682 |
| CCR2 | CXCL10 | ENSCAFP00000020334 | ENSCAFP00000032015 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.945 |
| CCR2 | CXCL12 | ENSCAFP00000020334 | ENSCAFP00000037130 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. | 0.938 |
| CCR2 | CXCL6 | ENSCAFP00000020334 | ENSCAFP00000034480 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-X-C motif chemokine. | 0.814 |
| CCR2 | CXCR2 | ENSCAFP00000020334 | ENSCAFP00000021547 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.761 |
| CCR2 | CXCR3 | ENSCAFP00000020334 | ENSCAFP00000025254 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.766 |
| CCR5 | CCR2 | ENSCAFP00000020323 | ENSCAFP00000020334 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.843 |
| CCR5 | CCR7 | ENSCAFP00000020323 | ENSCAFP00000041961 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | 0.476 |
| CCR5 | CX3CL1 | ENSCAFP00000020323 | ENSCAFP00000012877 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | Chemokine (C-X3-C motif) ligand 1. | 0.896 |
| CCR5 | CXCL10 | ENSCAFP00000020323 | ENSCAFP00000032015 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.957 |
| CCR5 | CXCL12 | ENSCAFP00000020323 | ENSCAFP00000037130 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. | 0.896 |
| CCR5 | CXCL6 | ENSCAFP00000020323 | ENSCAFP00000034480 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C motif chemokine. | 0.838 |
| CCR5 | CXCR2 | ENSCAFP00000020323 | ENSCAFP00000021547 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity). | 0.944 |
| CCR5 | CXCR3 | ENSCAFP00000020323 | ENSCAFP00000025254 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.683 |
| CCR7 | CCR2 | ENSCAFP00000041961 | ENSCAFP00000020334 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. | 0.699 |
| CCR7 | CCR5 | ENSCAFP00000041961 | ENSCAFP00000020323 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.476 |
| CCR7 | CX3CL1 | ENSCAFP00000041961 | ENSCAFP00000012877 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. | Chemokine (C-X3-C motif) ligand 1. | 0.867 |