STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)    
Predicted Functional Partners:
FZD3
Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.961
LRP6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.951
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.939
WIF1
WNT inhibitory factor 1.
    
 0.937
FZD7
Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.936
EBP
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
 0.935
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.934
FZD10
Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.932
DKK2
Dickkopf WNT signaling pathway inhibitor 2.
    
 0.930
SFRP2
Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.
    
 0.928
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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