TPRKB protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

TPRKB

Dual specificity phosphatase 11. (332 aa)

Predicted Functional Partners:

XRN1

0.831

INVS

0.721

SHROOM3

0.691

EIF5B

0.679

ENOSF1

0.676

DARS2

0.642

SUPT4H1

0.642

POLR2C

0.628

DUSP5

0.595

UBXN7

0.593

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DARS2	EIF5B	ENSCAFP00000021414	ENSCAFP00000003313	Aspartyl-tRNA synthetase 2, mitochondrial.	Eukaryotic translation initiation factor 5B.	0.445
DARS2	INVS	ENSCAFP00000021414	ENSCAFP00000050118	Aspartyl-tRNA synthetase 2, mitochondrial.	Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...]	0.650
DARS2	SHROOM3	ENSCAFP00000021414	ENSCAFP00000053352	Aspartyl-tRNA synthetase 2, mitochondrial.	Shroom family member 3.	0.609
DARS2	TPRKB	ENSCAFP00000021414	ENSCAFP00000012927	Aspartyl-tRNA synthetase 2, mitochondrial.	Dual specificity phosphatase 11.	0.642
DUSP5	TPRKB	ENSCAFP00000040487	ENSCAFP00000012927	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Dual specificity phosphatase 11.	0.595
EIF5B	DARS2	ENSCAFP00000003313	ENSCAFP00000021414	Eukaryotic translation initiation factor 5B.	Aspartyl-tRNA synthetase 2, mitochondrial.	0.445
EIF5B	POLR2C	ENSCAFP00000003313	ENSCAFP00000012825	Eukaryotic translation initiation factor 5B.	RNA polymerase II subunit C.	0.587
EIF5B	TPRKB	ENSCAFP00000003313	ENSCAFP00000012927	Eukaryotic translation initiation factor 5B.	Dual specificity phosphatase 11.	0.679
ENOSF1	TPRKB	ENSCAFP00000027117	ENSCAFP00000012927	Enolase superfamily member 1.	Dual specificity phosphatase 11.	0.676
INVS	DARS2	ENSCAFP00000050118	ENSCAFP00000021414	Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...]	Aspartyl-tRNA synthetase 2, mitochondrial.	0.650
INVS	SHROOM3	ENSCAFP00000050118	ENSCAFP00000053352	Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...]	Shroom family member 3.	0.729
INVS	TPRKB	ENSCAFP00000050118	ENSCAFP00000012927	Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...]	Dual specificity phosphatase 11.	0.721
POLR2C	EIF5B	ENSCAFP00000012825	ENSCAFP00000003313	RNA polymerase II subunit C.	Eukaryotic translation initiation factor 5B.	0.587
POLR2C	SUPT4H1	ENSCAFP00000012825	ENSCAFP00000025808	RNA polymerase II subunit C.	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	0.944
POLR2C	TPRKB	ENSCAFP00000012825	ENSCAFP00000012927	RNA polymerase II subunit C.	Dual specificity phosphatase 11.	0.628
POLR2C	UBXN7	ENSCAFP00000012825	ENSCAFP00000019156	RNA polymerase II subunit C.	UBX domain-containing protein 7.	0.597
SHROOM3	DARS2	ENSCAFP00000053352	ENSCAFP00000021414	Shroom family member 3.	Aspartyl-tRNA synthetase 2, mitochondrial.	0.609
SHROOM3	INVS	ENSCAFP00000053352	ENSCAFP00000050118	Shroom family member 3.	Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does n [...]	0.729
SHROOM3	TPRKB	ENSCAFP00000053352	ENSCAFP00000012927	Shroom family member 3.	Dual specificity phosphatase 11.	0.691
SUPT4H1	POLR2C	ENSCAFP00000025808	ENSCAFP00000012825	Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.	RNA polymerase II subunit C.	0.944