STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
OTULINLOTU deubiquitinase with linear linkage specificity like. (362 aa)    
Predicted Functional Partners:
TMEM63C
Transmembrane protein 63C.
      
 0.574
EVI2B
Ecotropic viral integration site 2B.
      
 0.542
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
    
 
 0.531
VCPIP1
Valosin containing protein interacting protein 1.
    
 
 0.515
FRMPD4
FERM and PDZ domain containing 4.
      
 0.483
TTC1
Tetratricopeptide repeat domain 1.
      
 0.475
PPP1R1A
Protein phosphatase 1 regulatory inhibitor subunit 1A.
      
 0.472
FKBP5
Peptidylprolyl isomerase.
      
 0.465
ZRANB1
Zinc finger RANBP2-type containing 1.
    
 
 0.431
ALG13
Uncharacterized protein.
      
 0.430
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.