STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1869 aa)    
Predicted Functional Partners:
ZDHHC22
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
    
 
 0.873
ELMO2
Engulfment and cell motility 2.
  
 
 0.846
IRF2BP1
Interferon regulatory factor 2 binding protein 1.
      
 0.816
ARL16
ADP ribosylation factor like GTPase 16.
      
 0.816
CYTH3
Cytohesin 3.
   
 
 0.808
ACVR1B
Activin A receptor type 1B.
    
 
 0.808
NUAK2
NUAK family kinase 2.
    
 
 0.802
RAC1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]
   
 0.767
ARHGEF17
Rho guanine nucleotide exchange factor 17.
      
 0.740
ELMO1
Engulfment and cell motility 1.
    
 
 0.718
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.