CALB1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CALB1

Calbindin 1. (261 aa)

Predicted Functional Partners:

RCVRN

0.836

TH

0.819

SST

0.819

SDF4

0.762

GFAP

0.738

GAD1

0.696

SLC17A7

0.668

SYP

0.651

CCK

0.627

CTBP2

0.621

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALB1	CCK	ENSCAFP00000013256	ENSCAFP00000065716	Calbindin 1.	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	0.627
CALB1	CTBP2	ENSCAFP00000013256	ENSCAFP00000051395	Calbindin 1.	C-terminal binding protein 2.	0.621
CALB1	GAD1	ENSCAFP00000013256	ENSCAFP00000039685	Calbindin 1.	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.	0.696
CALB1	GFAP	ENSCAFP00000013256	ENSCAFP00000058935	Calbindin 1.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.738
CALB1	RCVRN	ENSCAFP00000013256	ENSCAFP00000025716	Calbindin 1.	Recoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Impr [...]	0.836
CALB1	SDF4	ENSCAFP00000013256	ENSCAFP00000033564	Calbindin 1.	Stromal cell derived factor 4.	0.762
CALB1	SLC17A7	ENSCAFP00000013256	ENSCAFP00000005458	Calbindin 1.	Solute carrier family 17 member 7.	0.668
CALB1	SST	ENSCAFP00000013256	ENSCAFP00000064277	Calbindin 1.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.819
CALB1	SYP	ENSCAFP00000013256	ENSCAFP00000023239	Calbindin 1.	Synaptophysin.	0.651
CALB1	TH	ENSCAFP00000013256	ENSCAFP00000014845	Calbindin 1.	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.819
CCK	CALB1	ENSCAFP00000065716	ENSCAFP00000013256	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Calbindin 1.	0.627
CCK	GAD1	ENSCAFP00000065716	ENSCAFP00000039685	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.	0.518
CCK	GFAP	ENSCAFP00000065716	ENSCAFP00000058935	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.402
CCK	SST	ENSCAFP00000065716	ENSCAFP00000064277	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.965
CCK	SYP	ENSCAFP00000065716	ENSCAFP00000023239	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Synaptophysin.	0.521
CCK	TH	ENSCAFP00000065716	ENSCAFP00000014845	Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. cholecystokinin 58 and cholecystokinin 8, but not cholecystokinin 58 desnonopeptide, stimulate amylase release from the pancreas. cholecystokinin 58, but not cholecystokinin 8, increases bile-pancreatic volume.	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.773
CTBP2	CALB1	ENSCAFP00000051395	ENSCAFP00000013256	C-terminal binding protein 2.	Calbindin 1.	0.621
CTBP2	RCVRN	ENSCAFP00000051395	ENSCAFP00000025716	C-terminal binding protein 2.	Recoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Impr [...]	0.592
CTBP2	SYP	ENSCAFP00000051395	ENSCAFP00000023239	C-terminal binding protein 2.	Synaptophysin.	0.637
CTBP2	TH	ENSCAFP00000051395	ENSCAFP00000014845	C-terminal binding protein 2.	Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.	0.478