STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC12A3Solute carrier family 12 member 3. (1030 aa)    
Predicted Functional Partners:
KCNJ1
Potassium voltage-gated channel subfamily J member 1.
   
  
 0.817
AOC3
Amine oxidase copper containing 3.
   
 
 0.813
SLC5A2
Uncharacterized protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
   
  
 0.793
BSND
Barttin CLCNK type accessory beta subunit.
   
  
 0.740
WNK1
WNK lysine deficient protein kinase 1.
    
 
 0.737
KLHL2
Kelch like family member 2.
    
 
 0.686
TRPM6
Transient receptor potential cation channel subfamily M member 6.
   
  
 0.682
KCNJ6
Potassium voltage-gated channel subfamily J member 6.
   
  
 0.668
KCNJ9
Potassium voltage-gated channel subfamily J member 9.
   
  
 0.665
SCNN1B
Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...]
   
  
 0.658
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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