IL10RB protein (Canis lupus familiaris) - STRING interaction network

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Score

IL10RB

Interleukin 10 receptor subunit beta. (374 aa)

Predicted Functional Partners:

IFNLR1

0.993

IL10

0.990

IL10RA

0.988

IL22

0.986

IL26

0.953

TYK2

0.952

JAK1

0.951

LOC612539

0.925

IL29L

0.925

CTSS

0.906

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSS	IL10RA	ENSCAFP00000017782	ENSCAFP00000018903	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity).	Interleukin 10 receptor subunit alpha.	0.911
CTSS	IL10RB	ENSCAFP00000017782	ENSCAFP00000013342	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity).	Interleukin 10 receptor subunit beta.	0.906
IFNLR1	IL10	ENSCAFP00000042865	ENSCAFP00000016812	Interferon lambda receptor 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.758
IFNLR1	IL10RA	ENSCAFP00000042865	ENSCAFP00000018903	Interferon lambda receptor 1.	Interleukin 10 receptor subunit alpha.	0.413
IFNLR1	IL10RB	ENSCAFP00000042865	ENSCAFP00000013342	Interferon lambda receptor 1.	Interleukin 10 receptor subunit beta.	0.993
IFNLR1	IL22	ENSCAFP00000042865	ENSCAFP00000000592	Interferon lambda receptor 1.	Interleukin 22.	0.777
IFNLR1	IL29L	ENSCAFP00000042865	ENSCAFP00000016866	Interferon lambda receptor 1.	Interferon lambda.	0.982
IFNLR1	JAK1	ENSCAFP00000042865	ENSCAFP00000039978	Interferon lambda receptor 1.	Tyrosine-protein kinase.	0.992
IFNLR1	LOC612539	ENSCAFP00000042865	ENSCAFP00000008345	Interferon lambda receptor 1.	Uncharacterized protein.	0.979
IFNLR1	TYK2	ENSCAFP00000042865	ENSCAFP00000050119	Interferon lambda receptor 1.	Tyrosine-protein kinase.	0.915
IL10	IFNLR1	ENSCAFP00000016812	ENSCAFP00000042865	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interferon lambda receptor 1.	0.758
IL10	IL10RA	ENSCAFP00000016812	ENSCAFP00000018903	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit alpha.	0.997
IL10	IL10RB	ENSCAFP00000016812	ENSCAFP00000013342	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 10 receptor subunit beta.	0.990
IL10	IL22	ENSCAFP00000016812	ENSCAFP00000000592	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 22.	0.866
IL10	IL26	ENSCAFP00000016812	ENSCAFP00000000589	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Interleukin 26.	0.581
IL10	JAK1	ENSCAFP00000016812	ENSCAFP00000039978	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.775
IL10	TYK2	ENSCAFP00000016812	ENSCAFP00000050119	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	Tyrosine-protein kinase.	0.584
IL10RA	CTSS	ENSCAFP00000018903	ENSCAFP00000017782	Interleukin 10 receptor subunit alpha.	Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (By similarity).	0.911
IL10RA	IFNLR1	ENSCAFP00000018903	ENSCAFP00000042865	Interleukin 10 receptor subunit alpha.	Interferon lambda receptor 1.	0.413
IL10RA	IL10	ENSCAFP00000018903	ENSCAFP00000016812	Interleukin 10 receptor subunit alpha.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.997