STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HOMER1Homer scaffold protein 1. (354 aa)    
Predicted Functional Partners:
HOMER3
Homer scaffold protein 3.
    
0.994
GRM1
Glutamate metabotropic receptor 1.
    
 0.984
GRM5
Glutamate metabotropic receptor 5.
    
 0.969
C7H1orf116
Chromosome 7 C1orf116 homolog.
    
   0.926
HOMER2
Homer scaffold protein 2.
  
 
 
0.894
SYNGAP1
Synaptic Ras GTPase activating protein 1.
    
 
 0.878
GRIN1
Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
    
 
 0.804
TRAF5
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
   0.801
DBN1
Drebrin 1.
    
 
 0.800
SEMA4D
Semaphorin 4D; Belongs to the semaphorin family.
     
  0.798
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (46%) [HD]