STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PDP1Pyruvate dehyrogenase phosphatase catalytic subunit 1. (562 aa)    
Predicted Functional Partners:
PDHA1
Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
    
 
 0.798
PDK2
Protein-serine/threonine kinase.
   
 
 0.687
PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit.
   
 
 0.618
DLD
Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]
   
 
 0.604
GPLD1
Glycosylphosphatidylinositol specific phospholipase D1.
      
 0.595
PPTC7
Protein phosphatase; Belongs to the PP2C family.
    
 
 0.587
PDK3
Protein-serine/threonine kinase.
   
 
 0.585
PDHX
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.
   
 
 0.556
TPK1
Thiamin pyrophosphokinase 1.
     
 0.539
LETM1
Leucine zipper and EF-hand containing transmembrane protein 1.
      
 0.532
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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