CDH17 protein (Canis lupus familiaris) - STRING interaction network

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Score

CDH17

Cadherin 17. (832 aa)

Predicted Functional Partners:

CTNNB1

0.897

PRKAA1

0.842

CLDN12

0.784

TIMP2

0.734

MEP1A

0.728

CDX1

0.683

ATM

0.678

MUC13

0.676

CYP2R1

0.672

ITGB1

0.651

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	CDH17	ENSCAFP00000035996	ENSCAFP00000013461	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cadherin 17.	0.678
ATM	CTNNB1	ENSCAFP00000035996	ENSCAFP00000007783	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.429
ATM	PRKAA1	ENSCAFP00000035996	ENSCAFP00000050809	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-specific serine/threonine protein kinase.	0.641
CDH17	ATM	ENSCAFP00000013461	ENSCAFP00000035996	Cadherin 17.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.678
CDH17	CDX1	ENSCAFP00000013461	ENSCAFP00000026906	Cadherin 17.	Caudal type homeobox 1.	0.683
CDH17	CLDN12	ENSCAFP00000013461	ENSCAFP00000002765	Cadherin 17.	Claudin 12.	0.784
CDH17	CTNNB1	ENSCAFP00000013461	ENSCAFP00000007783	Cadherin 17.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.897
CDH17	CYP2R1	ENSCAFP00000013461	ENSCAFP00000012520	Cadherin 17.	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.672
CDH17	ITGB1	ENSCAFP00000013461	ENSCAFP00000005722	Cadherin 17.	Integrin beta; Belongs to the integrin beta chain family.	0.651
CDH17	MEP1A	ENSCAFP00000013461	ENSCAFP00000003016	Cadherin 17.	Meprin A subunit.	0.728
CDH17	MUC13	ENSCAFP00000013461	ENSCAFP00000042417	Cadherin 17.	Mucin 13, cell surface associated.	0.676
CDH17	PRKAA1	ENSCAFP00000013461	ENSCAFP00000050809	Cadherin 17.	Non-specific serine/threonine protein kinase.	0.842
CDH17	TIMP2	ENSCAFP00000013461	ENSCAFP00000035219	Cadherin 17.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.734
CDX1	CDH17	ENSCAFP00000026906	ENSCAFP00000013461	Caudal type homeobox 1.	Cadherin 17.	0.683
CLDN12	CDH17	ENSCAFP00000002765	ENSCAFP00000013461	Claudin 12.	Cadherin 17.	0.784
CLDN12	CYP2R1	ENSCAFP00000002765	ENSCAFP00000012520	Claudin 12.	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	0.581
CTNNB1	ATM	ENSCAFP00000007783	ENSCAFP00000035996	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.429
CTNNB1	CDH17	ENSCAFP00000007783	ENSCAFP00000013461	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Cadherin 17.	0.897
CTNNB1	ITGB1	ENSCAFP00000007783	ENSCAFP00000005722	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Integrin beta; Belongs to the integrin beta chain family.	0.607
CYP2R1	CDH17	ENSCAFP00000012520	ENSCAFP00000013461	Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family.	Cadherin 17.	0.672