STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AMFRAutocrine motility factor receptor. (574 aa)    
Predicted Functional Partners:
DERL1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
 0.982
VCP
Valosin containing protein; Belongs to the AAA ATPase family.
    
 0.980
UBE2G2
Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.976
FAF2
Fas associated factor family member 2.
    
 
 0.953
UBE2G1
Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.947
RPS27A
Ubiquitin-like domain-containing protein.
    
 0.945
ERLIN2
ER lipid raft associated 2.
    
 
 0.938
UBXN1
UBX domain protein 1.
    
 0.938
HERPUD1
Homocysteine inducible ER protein with ubiquitin like domain 1.
   
 
 0.937
BAG6
BCL2 associated athanogene 6.
    
 
 0.931
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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