RAPGEF3 protein (Canis lupus familiaris) - STRING interaction network

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Score

RAPGEF3

Rap guanine nucleotide exchange factor 3. (866 aa)

Predicted Functional Partners:

RAP1B

0.983

RAP1A

0.983

ADCY8

0.915

ADCY2

0.905

ADCY4

0.905

ADCY5

0.904

ADCY6

0.904

ADCY9

0.895

RRAS

0.895

ADCY7

0.894

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY2	ADCY4	ENSCAFP00000015076	ENSCAFP00000018143	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.827
ADCY2	ADCY5	ENSCAFP00000015076	ENSCAFP00000017783	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.677
ADCY2	ADCY6	ENSCAFP00000015076	ENSCAFP00000039800	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...]	0.677
ADCY2	ADCY7	ENSCAFP00000015076	ENSCAFP00000014604	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.829
ADCY2	ADCY8	ENSCAFP00000015076	ENSCAFP00000001538	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.802
ADCY2	ADCY9	ENSCAFP00000015076	ENSCAFP00000042267	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.911
ADCY2	RAPGEF3	ENSCAFP00000015076	ENSCAFP00000013515	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.905
ADCY4	ADCY2	ENSCAFP00000018143	ENSCAFP00000015076	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.827
ADCY4	ADCY5	ENSCAFP00000018143	ENSCAFP00000017783	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.801
ADCY4	ADCY6	ENSCAFP00000018143	ENSCAFP00000039800	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...]	0.885
ADCY4	ADCY7	ENSCAFP00000018143	ENSCAFP00000014604	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.950
ADCY4	ADCY8	ENSCAFP00000018143	ENSCAFP00000001538	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.940
ADCY4	ADCY9	ENSCAFP00000018143	ENSCAFP00000042267	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.954
ADCY4	RAPGEF3	ENSCAFP00000018143	ENSCAFP00000013515	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Rap guanine nucleotide exchange factor 3.	0.905
ADCY5	ADCY2	ENSCAFP00000017783	ENSCAFP00000015076	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.677
ADCY5	ADCY4	ENSCAFP00000017783	ENSCAFP00000018143	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.801
ADCY5	ADCY6	ENSCAFP00000017783	ENSCAFP00000039800	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion (By similarity). Signaling mediates cAMP-dependent activation of prot [...]	0.887
ADCY5	ADCY7	ENSCAFP00000017783	ENSCAFP00000014604	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.666
ADCY5	ADCY8	ENSCAFP00000017783	ENSCAFP00000001538	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.763
ADCY5	ADCY9	ENSCAFP00000017783	ENSCAFP00000042267	Adenylate cyclase type 5; [Isoform 1]: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.834