TBX5 protein (Canis lupus familiaris) - STRING interaction network

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Score

TBX5

T-box transcription factor 5. (519 aa)

Predicted Functional Partners:

NKX2-5

0.977

GATA4

0.934

WWTR1

0.931

MEF2C

0.867

HAND2

0.826

GATA5

0.792

NPPA

0.788

ISL1

0.786

HCN4

0.759

SMARCD3

0.750

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA4	GATA5	ENSCAFP00000038219	ENSCAFP00000018678	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	GATA binding protein 5.	0.440
GATA4	HAND2	ENSCAFP00000038219	ENSCAFP00000011616	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Heart and neural crest derivatives expressed 2.	0.801
GATA4	ISL1	ENSCAFP00000038219	ENSCAFP00000027248	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	ISL LIM homeobox 1.	0.663
GATA4	MEF2C	ENSCAFP00000038219	ENSCAFP00000053374	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Myocyte enhancer factor 2C.	0.864
GATA4	NKX2-5	ENSCAFP00000038219	ENSCAFP00000041395	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Transcription factor NKX2.5.	0.982
GATA4	NPPA	ENSCAFP00000038219	ENSCAFP00000053231	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.739
GATA4	SMARCD3	ENSCAFP00000038219	ENSCAFP00000007273	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3.	0.670
GATA4	TBX5	ENSCAFP00000038219	ENSCAFP00000013523	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	T-box transcription factor 5.	0.934
GATA5	GATA4	ENSCAFP00000018678	ENSCAFP00000038219	GATA binding protein 5.	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	0.440
GATA5	HAND2	ENSCAFP00000018678	ENSCAFP00000011616	GATA binding protein 5.	Heart and neural crest derivatives expressed 2.	0.592
GATA5	ISL1	ENSCAFP00000018678	ENSCAFP00000027248	GATA binding protein 5.	ISL LIM homeobox 1.	0.485
GATA5	NKX2-5	ENSCAFP00000018678	ENSCAFP00000041395	GATA binding protein 5.	Transcription factor NKX2.5.	0.898
GATA5	TBX5	ENSCAFP00000018678	ENSCAFP00000013523	GATA binding protein 5.	T-box transcription factor 5.	0.792
HAND2	GATA4	ENSCAFP00000011616	ENSCAFP00000038219	Heart and neural crest derivatives expressed 2.	Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes [...]	0.801
HAND2	GATA5	ENSCAFP00000011616	ENSCAFP00000018678	Heart and neural crest derivatives expressed 2.	GATA binding protein 5.	0.592
HAND2	ISL1	ENSCAFP00000011616	ENSCAFP00000027248	Heart and neural crest derivatives expressed 2.	ISL LIM homeobox 1.	0.534
HAND2	MEF2C	ENSCAFP00000011616	ENSCAFP00000053374	Heart and neural crest derivatives expressed 2.	Myocyte enhancer factor 2C.	0.731
HAND2	NKX2-5	ENSCAFP00000011616	ENSCAFP00000041395	Heart and neural crest derivatives expressed 2.	Transcription factor NKX2.5.	0.858
HAND2	NPPA	ENSCAFP00000011616	ENSCAFP00000053231	Heart and neural crest derivatives expressed 2.	Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family.	0.534
HAND2	SMARCD3	ENSCAFP00000011616	ENSCAFP00000007273	Heart and neural crest derivatives expressed 2.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3.	0.405