STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)    
Predicted Functional Partners:
FOSB
Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity.
   
 
 0.684
NCOR2
Nuclear receptor corepressor 2.
   
 0.623
EGR3
Early growth response 3.
   
 
 0.600
FOXA2
Forkhead box A2.
      
 0.581
EGR1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
   
 
 0.566
FOXN4
Forkhead box N4.
   
  
 0.564
BARHL2
BarH like homeobox 2.
      
 0.562
NCOR1
Nuclear receptor corepressor 1.
    
 0.562
ATF3
Activating transcription factor 3.
   
 
 0.560
NR4A3
Nuclear receptor subfamily 4 group A member 3.
  
  
0.560
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.