STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGR3Early growth response 3. (387 aa)    
Predicted Functional Partners:
EGR2
Early growth response 2.
   
 0.984
EP300
E1A binding protein p300.
    
 0.957
CREBBP
CREB binding protein.
    
 0.939
FOSB
Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity.
   
 0.734
NAB1
NGFI-A binding protein 1.
    
 
 0.732
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 
 0.692
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
   
 0.689
NPAS4
Neuronal PAS domain protein 4.
   
 
 0.657
NAB2
NGFI-A binding protein 2.
   
 
 0.649
JUND
JunD proto-oncogene, AP-1 transcription factor subunit.
   
 0.646
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.