| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CTSG | F2RL1 | ENSCAFP00000043060 | ENSCAFP00000013636 | Granzyme B; Belongs to the peptidase S1 family. | Protease-activated receptor 2. | 0.704 |
| CTSG | GZMA | ENSCAFP00000043060 | ENSCAFP00000026788 | Granzyme B; Belongs to the peptidase S1 family. | Granzyme A; Belongs to the peptidase S1 family. | 0.597 |
| CTSG | PLG | ENSCAFP00000043060 | ENSCAFP00000001078 | Granzyme B; Belongs to the peptidase S1 family. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.517 |
| EDN1 | F2RL1 | ENSCAFP00000014389 | ENSCAFP00000013636 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Protease-activated receptor 2. | 0.583 |
| EDN1 | GNA14 | ENSCAFP00000014389 | ENSCAFP00000041847 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | G protein subunit alpha 14. | 0.564 |
| EDN1 | GNAQ | ENSCAFP00000014389 | ENSCAFP00000028446 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.585 |
| EDN1 | KNG1 | ENSCAFP00000014389 | ENSCAFP00000020071 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Kininogen 1. | 0.707 |
| EDN1 | PLCB2 | ENSCAFP00000014389 | ENSCAFP00000013316 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.628 |
| F2RL1 | CTSG | ENSCAFP00000013636 | ENSCAFP00000043060 | Protease-activated receptor 2. | Granzyme B; Belongs to the peptidase S1 family. | 0.704 |
| F2RL1 | EDN1 | ENSCAFP00000013636 | ENSCAFP00000014389 | Protease-activated receptor 2. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.583 |
| F2RL1 | GNA14 | ENSCAFP00000013636 | ENSCAFP00000041847 | Protease-activated receptor 2. | G protein subunit alpha 14. | 0.581 |
| F2RL1 | GNAQ | ENSCAFP00000013636 | ENSCAFP00000028446 | Protease-activated receptor 2. | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. | 0.910 |
| F2RL1 | GZMA | ENSCAFP00000013636 | ENSCAFP00000026788 | Protease-activated receptor 2. | Granzyme A; Belongs to the peptidase S1 family. | 0.665 |
| F2RL1 | KNG1 | ENSCAFP00000013636 | ENSCAFP00000020071 | Protease-activated receptor 2. | Kininogen 1. | 0.588 |
| F2RL1 | LOC475521 | ENSCAFP00000013636 | ENSCAFP00000005682 | Protease-activated receptor 2. | Cationic trypsin. | 0.747 |
| F2RL1 | PLCB2 | ENSCAFP00000013636 | ENSCAFP00000013316 | Protease-activated receptor 2. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.574 |
| F2RL1 | PLG | ENSCAFP00000013636 | ENSCAFP00000001078 | Protease-activated receptor 2. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.683 |
| F2RL1 | PRSS2 | ENSCAFP00000013636 | ENSCAFP00000043963 | Protease-activated receptor 2. | Anionic trypsin. | 0.736 |
| GNA14 | EDN1 | ENSCAFP00000041847 | ENSCAFP00000014389 | G protein subunit alpha 14. | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.564 |
| GNA14 | F2RL1 | ENSCAFP00000041847 | ENSCAFP00000013636 | G protein subunit alpha 14. | Protease-activated receptor 2. | 0.581 |