STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SERPINB1Serpin family B member 1; Belongs to the serpin family. (378 aa)    
Predicted Functional Partners:
DNPH1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
      
 0.798
TES
Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity); Belongs to the prickle / espinas / testin family.
    
 
 0.772
SERPING1
Serpin family G member 1; Belongs to the serpin family.
  
 0.726
CNDP2
Carnosine dipeptidase 2.
   
  
 0.606
MMP24
Matrix metallopeptidase 24.
    
 
 0.602
BCAM
Basal cell adhesion molecule.
      
 0.533
CTSG
Granzyme B; Belongs to the peptidase S1 family.
   
 0.525
AGT
Angiotensinogen; Belongs to the serpin family.
  
  
 0.514
ELANE
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
   
 0.501
F2
Coagulation factor II, thrombin; Belongs to the peptidase S1 family.
   
 0.492
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.