LOC100856622 protein (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

LOC100856622

Uncharacterized protein. (569 aa)

Predicted Functional Partners:

MCM2

0.869

MCM3

0.812

GINS4

0.789

GINS1

0.785

CDC45

0.780

GINS2

0.775

MCM4

0.772

MCM6

0.769

PRIM2

0.742

MCM5

0.742

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	GINS1	ENSCAFP00000021510	ENSCAFP00000038461	Cell division cycle 45.	GINS complex subunit 1.	0.965
CDC45	GINS2	ENSCAFP00000021510	ENSCAFP00000049326	Cell division cycle 45.	GINS complex subunit 2.	0.990
CDC45	GINS4	ENSCAFP00000021510	ENSCAFP00000008567	Cell division cycle 45.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.972
CDC45	LOC100856622	ENSCAFP00000021510	ENSCAFP00000013698	Cell division cycle 45.	Uncharacterized protein.	0.780
CDC45	MCM2	ENSCAFP00000021510	ENSCAFP00000042269	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.998
CDC45	MCM3	ENSCAFP00000021510	ENSCAFP00000003211	Cell division cycle 45.	Minichromosome maintenance complex component 3; Belongs to the MCM family.	0.992
CDC45	MCM4	ENSCAFP00000021510	ENSCAFP00000009885	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.992
CDC45	MCM5	ENSCAFP00000021510	ENSCAFP00000050329	Cell division cycle 45.	Minichromosome maintenance complex component 5; Belongs to the MCM family.	0.996
CDC45	MCM6	ENSCAFP00000021510	ENSCAFP00000007692	Cell division cycle 45.	DNA helicase; Belongs to the MCM family.	0.996
CDC45	PRIM2	ENSCAFP00000021510	ENSCAFP00000030957	Cell division cycle 45.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.977
GINS1	CDC45	ENSCAFP00000038461	ENSCAFP00000021510	GINS complex subunit 1.	Cell division cycle 45.	0.965
GINS1	GINS2	ENSCAFP00000038461	ENSCAFP00000049326	GINS complex subunit 1.	GINS complex subunit 2.	0.999
GINS1	GINS4	ENSCAFP00000038461	ENSCAFP00000008567	GINS complex subunit 1.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.998
GINS1	LOC100856622	ENSCAFP00000038461	ENSCAFP00000013698	GINS complex subunit 1.	Uncharacterized protein.	0.785
GINS1	MCM2	ENSCAFP00000038461	ENSCAFP00000042269	GINS complex subunit 1.	DNA helicase; Belongs to the MCM family.	0.941
GINS1	MCM3	ENSCAFP00000038461	ENSCAFP00000003211	GINS complex subunit 1.	Minichromosome maintenance complex component 3; Belongs to the MCM family.	0.950
GINS1	MCM4	ENSCAFP00000038461	ENSCAFP00000009885	GINS complex subunit 1.	DNA helicase; Belongs to the MCM family.	0.944
GINS1	MCM5	ENSCAFP00000038461	ENSCAFP00000050329	GINS complex subunit 1.	Minichromosome maintenance complex component 5; Belongs to the MCM family.	0.950
GINS1	MCM6	ENSCAFP00000038461	ENSCAFP00000007692	GINS complex subunit 1.	DNA helicase; Belongs to the MCM family.	0.938
GINS1	PRIM2	ENSCAFP00000038461	ENSCAFP00000030957	GINS complex subunit 1.	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.	0.812