STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIPK1Receptor interacting serine/threonine kinase 1. (669 aa)    
Predicted Functional Partners:
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.999
TRADD
TNFRSF1A associated via death domain.
    
 0.999
RIPK3
Protein kinase domain-containing protein.
  
0.999
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding protein 2.
    
 0.997
TNFRSF1A
TNF receptor superfamily member 1A.
   
 0.997
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.996
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
  
0.996
USP21
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
    
 0.996
TNFAIP3
TNF alpha induced protein 3.
   
 0.995
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.995
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (18%) [HD]