PKP4 protein (Canis lupus familiaris) - STRING interaction network

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PKP4

Plakophilin 4. (1222 aa)

Predicted Functional Partners:

ERBIN

0.850

JUP

0.835

TCF7L1

0.788

TCF7L2

0.778

CTNNB1

0.777

PPFIA4

0.775

ZBTB33

0.775

LEF1

0.772

TCF7

0.769

CDH5

0.715

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDH5	CTNNB1	ENSCAFP00000030279	ENSCAFP00000007783	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.999
CDH5	JUP	ENSCAFP00000030279	ENSCAFP00000023403	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.987
CDH5	PKP4	ENSCAFP00000030279	ENSCAFP00000013791	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Plakophilin 4.	0.715
CTNNB1	CDH5	ENSCAFP00000007783	ENSCAFP00000030279	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.999
CTNNB1	JUP	ENSCAFP00000007783	ENSCAFP00000023403	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Uncharacterized protein.	0.997
CTNNB1	LEF1	ENSCAFP00000007783	ENSCAFP00000056485	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Lymphoid enhancer binding factor 1.	0.999
CTNNB1	PKP4	ENSCAFP00000007783	ENSCAFP00000013791	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Plakophilin 4.	0.777
CTNNB1	TCF7	ENSCAFP00000007783	ENSCAFP00000043629	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Transcription factor 7.	0.998
CTNNB1	TCF7L1	ENSCAFP00000007783	ENSCAFP00000011603	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Transcription factor 7 like 1.	0.992
CTNNB1	TCF7L2	ENSCAFP00000007783	ENSCAFP00000039879	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Transcription factor 7 like 2.	0.997
CTNNB1	ZBTB33	ENSCAFP00000007783	ENSCAFP00000031837	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Zinc finger and BTB domain containing 33.	0.448
ERBIN	JUP	ENSCAFP00000064102	ENSCAFP00000023403	Erbb2 interacting protein.	Uncharacterized protein.	0.507
ERBIN	PKP4	ENSCAFP00000064102	ENSCAFP00000013791	Erbb2 interacting protein.	Plakophilin 4.	0.850
ERBIN	ZBTB33	ENSCAFP00000064102	ENSCAFP00000031837	Erbb2 interacting protein.	Zinc finger and BTB domain containing 33.	0.617
JUP	CDH5	ENSCAFP00000023403	ENSCAFP00000030279	Uncharacterized protein.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.987
JUP	CTNNB1	ENSCAFP00000023403	ENSCAFP00000007783	Uncharacterized protein.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.997
JUP	ERBIN	ENSCAFP00000023403	ENSCAFP00000064102	Uncharacterized protein.	Erbb2 interacting protein.	0.507
JUP	LEF1	ENSCAFP00000023403	ENSCAFP00000056485	Uncharacterized protein.	Lymphoid enhancer binding factor 1.	0.946
JUP	PKP4	ENSCAFP00000023403	ENSCAFP00000013791	Uncharacterized protein.	Plakophilin 4.	0.835
JUP	TCF7	ENSCAFP00000023403	ENSCAFP00000043629	Uncharacterized protein.	Transcription factor 7.	0.947