STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPINT1Serine peptidase inhibitor, Kunitz type 1. (545 aa)    
Predicted Functional Partners:
ST14
Suppression of tumorigenicity 14.
   
 
 0.958
HGF
Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.876
HGFAC
Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family.
    
 
 0.831
MST1
Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily.
    
 0.821
F12
Coagulation factor XII.
    
 
 0.756
MSH2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
      
 0.612
SPINT4
Serine peptidase inhibitor, Kunitz type 4.
      
 0.592
MLH1
MutL homolog 1.
      
 0.581
HPN
Hepsin; Belongs to the peptidase S1 family.
   
 
 0.579
SPINT3
Early lactation protein.
   
  
 0.556
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.