node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHM | GDI2 | ENSCAFP00000048589 | ENSCAFP00000007805 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.460 |
CHM | HPS1 | ENSCAFP00000048589 | ENSCAFP00000013804 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | 0.402 |
CHM | HPS4 | ENSCAFP00000048589 | ENSCAFP00000017261 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | 0.400 |
CHM | RAB15 | ENSCAFP00000048589 | ENSCAFP00000023834 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | RAB15, member RAS oncogene family. | 0.636 |
CHM | RAB25 | ENSCAFP00000048589 | ENSCAFP00000024805 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). | 0.620 |
CHM | RAB29 | ENSCAFP00000048589 | ENSCAFP00000014955 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | RAB29, member RAS oncogene family. | 0.748 |
CHM | RAB32 | ENSCAFP00000048589 | ENSCAFP00000042453 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | RAB32, member RAS oncogene family. | 0.627 |
CHM | RAB38 | ENSCAFP00000048589 | ENSCAFP00000006534 | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | RAB38, member RAS oncogene family. | 0.618 |
GDI2 | CHM | ENSCAFP00000007805 | ENSCAFP00000048589 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | 0.460 |
GDI2 | HPS1 | ENSCAFP00000007805 | ENSCAFP00000013804 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | 0.400 |
GDI2 | HPS4 | ENSCAFP00000007805 | ENSCAFP00000017261 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. | 0.415 |
GDI2 | RAB15 | ENSCAFP00000007805 | ENSCAFP00000023834 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | RAB15, member RAS oncogene family. | 0.478 |
GDI2 | RAB25 | ENSCAFP00000007805 | ENSCAFP00000024805 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity). | 0.565 |
GDI2 | RAB32 | ENSCAFP00000007805 | ENSCAFP00000042453 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | RAB32, member RAS oncogene family. | 0.554 |
GDI2 | RAB38 | ENSCAFP00000007805 | ENSCAFP00000006534 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | RAB38, member RAS oncogene family. | 0.592 |
GTF2H1 | HPS1 | ENSCAFP00000013505 | ENSCAFP00000013804 | General transcription factor IIH subunit 1. | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | 0.424 |
GTF2H1 | HPS3 | ENSCAFP00000013505 | ENSCAFP00000057884 | General transcription factor IIH subunit 1. | Hermansky-Pudlak syndrome 3 protein homolog; Involved in early stages of melanosome biogenesis and maturation. | 0.575 |
HPS1 | CHM | ENSCAFP00000013804 | ENSCAFP00000048589 | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. | 0.402 |
HPS1 | GDI2 | ENSCAFP00000013804 | ENSCAFP00000007805 | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.400 |
HPS1 | GTF2H1 | ENSCAFP00000013804 | ENSCAFP00000013505 | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. | General transcription factor IIH subunit 1. | 0.424 |