DLL4 protein (Canis lupus familiaris) - STRING interaction network

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Score

DLL4

Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (732 aa)

Predicted Functional Partners:

NOTCH1

0.976

NOTCH4

0.968

NOTCH3

0.953

NOTCH2

0.944

DLL1

0.881

HEY1

0.859

RBPJ

0.855

EFNB2

0.809

EYS

0.782

EYS-2

0.782

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL4	ENSCAFP00000006075	ENSCAFP00000013852	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.881
DLL1	EYS	ENSCAFP00000006075	ENSCAFP00000003634	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.859
DLL1	EYS-2	ENSCAFP00000006075	ENSCAFP00000052143	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.859
DLL1	HEY1	ENSCAFP00000006075	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.769
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.981
DLL1	NOTCH2	ENSCAFP00000006075	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.963
DLL1	NOTCH3	ENSCAFP00000006075	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL1	NOTCH4	ENSCAFP00000006075	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.976
DLL1	RBPJ	ENSCAFP00000006075	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.875
DLL4	DLL1	ENSCAFP00000013852	ENSCAFP00000006075	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.881
DLL4	EFNB2	ENSCAFP00000013852	ENSCAFP00000052146	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Ephrin B2; Belongs to the ephrin family.	0.809
DLL4	EYS	ENSCAFP00000013852	ENSCAFP00000003634	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.782
DLL4	EYS-2	ENSCAFP00000013852	ENSCAFP00000052143	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.782
DLL4	HEY1	ENSCAFP00000013852	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.859
DLL4	NOTCH1	ENSCAFP00000013852	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.976
DLL4	NOTCH2	ENSCAFP00000013852	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.944
DLL4	NOTCH3	ENSCAFP00000013852	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.953
DLL4	NOTCH4	ENSCAFP00000013852	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.968
DLL4	RBPJ	ENSCAFP00000013852	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.855
EFNB2	DLL4	ENSCAFP00000052146	ENSCAFP00000013852	Ephrin B2; Belongs to the ephrin family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.809