STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.887
GABARAPL1
GABA type A receptor associated protein like 1.
    
 0.806
VMP1
Vacuole membrane protein 1.
     
 0.738
GABARAP
GABA type A receptor-associated protein.
    
 0.718
GABARAPL2
GABA type A receptor associated protein like 2.
    
 0.699
MAP1LC3C
Microtubule associated protein 1 light chain 3 gamma.
    
 0.689
MAP1LC3B
Uncharacterized protein.
    
 0.665
ENSCAFP00000047975
Uncharacterized protein.
    
 0.665
DYNLRB1
Dynein light chain roadblock-type 1.
    
 0.665
HIPK2
Homeodomain interacting protein kinase 2.
    
 0.636
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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