MMP2 protein (Canis lupus familiaris) - STRING interaction network

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Score

MMP2

Matrix metallopeptidase 2. (610 aa)

Predicted Functional Partners:

TIMP3

0.931

MMP14

0.897

TIMP2

0.887

THBS1

0.871

MMP9

0.859

SRC

0.852

EDN1

0.841

HBEGF

0.824

CYBB

0.814

NCF4

0.807

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYBB	EDN1	ENSCAFP00000020532	ENSCAFP00000014389	Cytochrome b-245 beta chain.	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	0.490
CYBB	MMP2	ENSCAFP00000020532	ENSCAFP00000013872	Cytochrome b-245 beta chain.	Matrix metallopeptidase 2.	0.814
CYBB	MMP9	ENSCAFP00000020532	ENSCAFP00000035167	Cytochrome b-245 beta chain.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.881
CYBB	NCF4	ENSCAFP00000020532	ENSCAFP00000002195	Cytochrome b-245 beta chain.	Neutrophil cytosolic factor 4.	0.954
EDN1	CYBB	ENSCAFP00000014389	ENSCAFP00000020532	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Cytochrome b-245 beta chain.	0.490
EDN1	MMP2	ENSCAFP00000014389	ENSCAFP00000013872	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Matrix metallopeptidase 2.	0.841
EDN1	MMP9	ENSCAFP00000014389	ENSCAFP00000035167	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.954
EDN1	SRC	ENSCAFP00000014389	ENSCAFP00000044994	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Tyrosine-protein kinase.	0.407
EDN1	THBS1	ENSCAFP00000014389	ENSCAFP00000012843	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Thrombospondin 1.	0.475
EDN1	TIMP2	ENSCAFP00000014389	ENSCAFP00000035219	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.489
EDN1	TIMP3	ENSCAFP00000014389	ENSCAFP00000040576	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family.	TIMP metallopeptidase inhibitor 3.	0.425
HBEGF	MMP14	ENSCAFP00000051029	ENSCAFP00000016472	Heparin binding EGF like growth factor.	Matrix metallopeptidase 14.	0.905
HBEGF	MMP2	ENSCAFP00000051029	ENSCAFP00000013872	Heparin binding EGF like growth factor.	Matrix metallopeptidase 2.	0.824
HBEGF	MMP9	ENSCAFP00000051029	ENSCAFP00000035167	Heparin binding EGF like growth factor.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.920
HBEGF	SRC	ENSCAFP00000051029	ENSCAFP00000044994	Heparin binding EGF like growth factor.	Tyrosine-protein kinase.	0.674
MMP14	HBEGF	ENSCAFP00000016472	ENSCAFP00000051029	Matrix metallopeptidase 14.	Heparin binding EGF like growth factor.	0.905
MMP14	MMP2	ENSCAFP00000016472	ENSCAFP00000013872	Matrix metallopeptidase 14.	Matrix metallopeptidase 2.	0.897
MMP14	MMP9	ENSCAFP00000016472	ENSCAFP00000035167	Matrix metallopeptidase 14.	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).	0.454
MMP14	NCF4	ENSCAFP00000016472	ENSCAFP00000002195	Matrix metallopeptidase 14.	Neutrophil cytosolic factor 4.	0.580
MMP14	SRC	ENSCAFP00000016472	ENSCAFP00000044994	Matrix metallopeptidase 14.	Tyrosine-protein kinase.	0.464