STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2495 aa)    
Predicted Functional Partners:
APC
APC regulator of WNT signaling pathway.
   
 
 0.804
RAPGEF6
Uncharacterized protein.
   
 
 0.737
TMEM229B
Transmembrane protein 229B.
      
 0.724
RAPGEF2
Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]
   
 
 0.634
PKDREJ
Polycystin family receptor for egg jelly.
      
 0.600
APC2
APC regulator of WNT signaling pathway 2.
   
 
 0.597
LRRC2
Leucine rich repeat containing 2.
    
 
 0.596
ADAM20
ADAM metallopeptidase domain 20.
      
 0.586
WBP2
WW domain binding protein 2.
   
  
 0.571
MAP3K3
Mitogen-activated protein kinase kinase kinase 3.
   
 
 0.568
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.