STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (972 aa)    
Predicted Functional Partners:
TDRD9
Tudor domain containing 9.
   
 
 0.853
DALRD3
DALR anticodon binding domain containing 3.
      
 0.811
TDRD6
Tudor domain containing 6.
   
 
 0.775
TDRD1
Tudor domain containing 1.
   
 
 0.775
TDRD15
Tudor domain containing 15.
   
 
 0.775
DAZL
Deleted in azoospermia like.
   
 
 0.753
TDRD5
Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity); Belongs to the TDRD5 family.
   
 
 0.708
TDRKH
Tudor and KH domain containing.
   
 
 0.692
DICER1
Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.
    
 
 0.691
ARHGAP20
Rho GTPase activating protein 20.
      
 0.689
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.