STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MARCHF7Membrane associated ring-CH-type finger 7. (708 aa)    
Predicted Functional Partners:
UBE2K
Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.825
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
    
 
 0.823
TGFBR2
TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]
    
   0.737
HM13
Histocompatibility minor 13.
   
 
 0.655
RNF19A
RBR-type E3 ubiquitin transferase.
   
  
 0.640
USP14
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
   
  
 0.640
PSME4
Proteasome activator subunit 4.
   
  
 0.618
UBE2A
Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.618
ASCC3
Activating signal cointegrator 1 complex subunit 3.
   
  
 0.612
IFT88
Intraflagellar transport 88.
      
 0.612
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.