DENND2C protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DENND2C

DENN domain containing 2C. (937 aa)

Predicted Functional Partners:

RAB9B

0.833

C20H3orf67

0.726

RAB9A

0.700

RHOBTB3

0.611

AVL9

0.524

KIF2B

0.475

SYTL1

0.472

PIGX

0.470

CHM

0.429

TPCN2

0.404

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AVL9	DENND2C	ENSCAFP00000004693	ENSCAFP00000013963	AVL9 cell migration associated.	DENN domain containing 2C.	0.524
AVL9	RAB9B	ENSCAFP00000004693	ENSCAFP00000026282	AVL9 cell migration associated.	RAB9B, member RAS oncogene family.	0.418
C20H3orf67	DENND2C	ENSCAFP00000055936	ENSCAFP00000013963	Chromosome 20 C3orf67 homolog.	DENN domain containing 2C.	0.726
CHM	DENND2C	ENSCAFP00000048589	ENSCAFP00000013963	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	DENN domain containing 2C.	0.429
CHM	RAB9A	ENSCAFP00000048589	ENSCAFP00000017285	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family.	0.816
CHM	RAB9B	ENSCAFP00000048589	ENSCAFP00000026282	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	RAB9B, member RAS oncogene family.	0.821
DENND2C	AVL9	ENSCAFP00000013963	ENSCAFP00000004693	DENN domain containing 2C.	AVL9 cell migration associated.	0.524
DENND2C	C20H3orf67	ENSCAFP00000013963	ENSCAFP00000055936	DENN domain containing 2C.	Chromosome 20 C3orf67 homolog.	0.726
DENND2C	CHM	ENSCAFP00000013963	ENSCAFP00000048589	DENN domain containing 2C.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.429
DENND2C	KIF2B	ENSCAFP00000013963	ENSCAFP00000025537	DENN domain containing 2C.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.475
DENND2C	PIGX	ENSCAFP00000013963	ENSCAFP00000019199	DENN domain containing 2C.	Phosphatidylinositol glycan anchor biosynthesis class X.	0.470
DENND2C	RAB9A	ENSCAFP00000013963	ENSCAFP00000017285	DENN domain containing 2C.	Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family.	0.700
DENND2C	RAB9B	ENSCAFP00000013963	ENSCAFP00000026282	DENN domain containing 2C.	RAB9B, member RAS oncogene family.	0.833
DENND2C	RHOBTB3	ENSCAFP00000013963	ENSCAFP00000011685	DENN domain containing 2C.	Rho related BTB domain containing 3.	0.611
DENND2C	SYTL1	ENSCAFP00000013963	ENSCAFP00000063870	DENN domain containing 2C.	Synaptotagmin like 1.	0.472
DENND2C	TPCN2	ENSCAFP00000013963	ENSCAFP00000015788	DENN domain containing 2C.	Two pore segment channel 2.	0.404
KIF2B	DENND2C	ENSCAFP00000025537	ENSCAFP00000013963	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	DENN domain containing 2C.	0.475
PIGX	DENND2C	ENSCAFP00000019199	ENSCAFP00000013963	Phosphatidylinositol glycan anchor biosynthesis class X.	DENN domain containing 2C.	0.470
RAB9A	CHM	ENSCAFP00000017285	ENSCAFP00000048589	Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family.	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.	0.816
RAB9A	DENND2C	ENSCAFP00000017285	ENSCAFP00000013963	Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). Belongs to the small GTPase superfamily. Rab family.	DENN domain containing 2C.	0.700